MEGA-ACE (Multi-disciplinary Educational Global Alliance for Algorand Centre of Excellence) is an inspiring academic endeavour composed of 17 institutions across 6 continents, forming a powerhouse of multi-disciplinary blockchain research and education. Other than the centre at IIT Bombay, MEGA-ACE includes academics and researchers from Purdue University, Cornell University, UCLA, Rensselaer Polytechnic Institute, Texas A&M, Bar Ilan University, Reichman University, Stealth, IIT Madras, Ecole Polytechnique France, National Technical University Athens, Universidad Nacional Autonoma de Mexico, University of Buenos Aires, CoinFabrik, Australia National University, and the University of Nairobi.MEGA-ACE aims to transform the blockchain landscape. Motivated by concrete problems, it targets the construction of end-to-end solutions, from foundational theory right through to applications. The ACE combines multidisciplinary approaches, from economics and social choice to cryptography and blockchain architectures.